The nociceptin/orphanin FQ receptor (NOP-R)
A) is genetically related to the classical opioid receptors, μ, δ, and κ.
B) has a high binding affinity for the endogenous opioids.
C) is found only in limbic areas and the spinal cord.
D) produces euphoria when activated.

Question

Quizplus · Accepted Answer

The nociceptin/orphanin FQ receptor (NOP-R) is genetically related to the classical opioid receptors, μ, δ, and κ. However, it differs from them in its selective binding to the endogenous ligand nociceptin/orphanin FQ, rather than to the endorphins or enkephalins. NOP-R is not a receptor for the endogenous opioids.

The Nociceptin/orphanin FQ Receptor (NOP-R)