Which statement about the role of the endogenous opioid system in alcohol's reinforcing effects is false?
A) Mice that lack the μ-opioid receptor do not self-administer alcohol.
B) Opioid receptor antagonists reduce alcohol self-administration in animals.
C) Clinical trials show that opioid receptor antagonists reduce alcohol craving and relapse in humans.
D) Chronic alcohol use increases gene expression of endorphin and enkephalin.

Question

Quizplus · Accepted Answer

The statement that chronic alcohol use increases gene expression of endorphin and enkephalin is false. Chronic alcohol use actually decreases gene expression of endorphin and enkephalin in the brain, leading to a deficit in the endogenous opioid system and contributing to alcohol dependence.

Which Statement About the Role of the Endogenous Opioid System