The increase in threshold for electrical self-stimulation of the brain produced by withdrawal from chronic treatment with drugs of abuse is generally interpreted to indicate a(n)

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Quizplus · Accepted Answer

The increase in threshold for electrical self-stimulation of the brain indicates a decrease in sensitivity of the reward circuit, which is a common consequence of chronic drug abuse. This shift in reward circuitry may contribute to the development of tolerance to drug effects and the need for higher doses to achieve the same effects, as well as potentially increasing the risk of relapse.

The Increase in Threshold for Electrical Self-Stimulation of the Brain