Which of the following is thought to be responsible for the anticonvulsant action of neurosteriods in type II (hormone withdrawal) catamenial epilepsy? A) Upregulation of benzodiazepine receptors B) Downregulation of benzodiazepine receptors C) Upregulation of δ subunit-containing extrasynaptic GABA_A receptors D) Downregulation of A5 subunit-containing extrasynaptic GABA_A receptors

Question

Quizplus · Accepted Answer

Neurosteroids are known to upregulate the expression of the δ subunit-containing extrasynaptic GABA receptors, which contain the GABA_A receptor. This leads to increased inhibitory effects on neurons and decreased susceptibility to seizures. Benzodiazepine receptors are not directly involved in the anticonvulsant action of neurosteroids in catamenial epilepsy.

Which of the Following Is Thought to Be Responsible for the Anticonvulsant