Traditional medications used to treat migraines work by constricting blood vessels. In contrast the 5-HT1F agonist lasmiditan acts by

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Lasmiditan acts by decreasing activity within the pain pathway, specifically by binding to and activating 5-HT1F receptors on trigeminal nerve endings, which reduces the release of pro-inflammatory neuropeptides and ultimately leads to pain relief. It does not affect blood vessels, blood pressure, or endorphin release.

Traditional Medications Used to Treat Migraines Work by Constricting Blood