Activation of terminal autoreceptors inhibits dopamine release, in part, by A) increasing Cl^- entry into the terminal. B) decreasing Ca²⁺ entry into the terminal. C) preventing reuptake into vesicles. D) decreasing Na⁺ entry into the terminal.

Question

Quizplus · Accepted Answer

Activation of autoreceptors on dopamine terminals inhibits dopamine release by decreasing Ca2+ entry into the terminal. This reduces the amount of dopamine that can be released from the vesicles. Option A is incorrect because Cl- does not play a role in dopamine release. Option C is incorrect because autoreceptors do not affect the reuptake of dopamine. Option D is incorrect because Na+ entry is not directly involved in dopamine release, although it is involved in the generation of action potentials that lead to the opening of Ca2+ channels.

Activation of Terminal Autoreceptors Inhibits Dopamine Release, in Part, by