Local anesthetics, such as lidocaine, have their effects by A) blocking the Na⁺-K⁺ pump. B) preventing the generation of EPSPs and IPSPs. C) blocking voltage-gated Ca²⁺ channels. D) blocking voltage-gated Na⁺ channels.

Question

Quizplus · Accepted Answer

Local anesthetics like lidocaine block voltage-gated Na+ channels, which are responsible for the initiation and propagation of action potentials in neurons. By blocking these channels, lidocaine prevents the influx of Na+ ions, thereby preventing depolarization of the membrane and the initiation of action potentials. This results in the loss of sensation in the affected area.

Local Anesthetics, Such as Lidocaine, Have Their Effects by