After chronic use, the need to administer more of a drug to achieve the same drug effect is known as

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Tolerance is the phenomenon where repeated use of a drug leads to a decreased effect, necessitating an increase in the dose to achieve the same effect. Sensitization is the opposite of tolerance and occurs when the drug's effect increases with repeated use. Antagonism refers to the inhibitory effect of a drug on the action of another drug, while potentiation refers to the increased effect of a drug when used in combination with another drug.

After Chronic Use, the Need to Administer More of a Drug