Although monoamine oxidase inhibitors (MAOIs) are effective in treating certain anxiety disorders, they have significant drawbacks regarding the possibility of:

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MAOIs can lead to a serious hypertensive crisis if the patient consumes certain foods or beverages containing tyramine or sympathomimetic drugs while taking MAOIs. This can cause a very sudden and dangerous increase in blood pressure that can lead to stroke or even death. While anaphylactic reactions and over-sedation are possible side effects of MAOIs, they are not as commonly seen or as dangerous as hypertensive crises. Immune suppression is not typically associated with the use of MAOIs.

Although Monoamine Oxidase Inhibitors (MAOIs) Are Effective in Treating Certain