Fatigue Is a Complicated Issue Linked to Reduced Physical and Mental

Fatigue is a complicated issue linked to reduced physical and mental performance and alertness. Fatigue is associated with a variety of factors, including sleep requirements, continuous hours awake, and circadian rhythms. Which one is correct about fatigue?

A) Pilots become accustomed to fatigue over time, and it has less of an impact.
B) Jet lag doesn't result in fatigue.
C) People who sleep only one hour less than required demonstrate high alertness the following day.
D) Continuous hours awake can also negatively impact performance.
E) All of the above