Forward genetics involves disruption of a known gene to see what phenotypes will be produced. Reverse genetics involves introducing random mutations and examining the resultant phenotypes to discover the causative gene.

Question

Quizplus · Accepted Answer

In forward genetics, unbiased mutagenesis of a genome produces a range of mutants with different phenotypes. The mutant with the phenotype of interest is then examined to discover the responsible gene. In reverse genetics, a known gene is disrupted to determine its phenotype.

Forward Genetics Involves Disruption of a Known Gene to See