Biochemically similar amino acids are likely to have similar codons. This reduces the chance that a mutation will cause an amino acid to be substituted with a different amino acid.

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Similar amino acids are likely to have similar codons. This does not reduce the chance that a mutation will result in an amino acid substitution. However, this does increase that chance that any replacement amino acid would be biochemically similar and therefore less likely to have a deleterious effect on the protein.

Biochemically Similar Amino Acids Are Likely to Have Similar Codons