Which occurs during the stabilizing of a potentiated synapse?

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Quizplus · Accepted Answer

During the stabilizing of a potentiated synapse, the UPS (Ubiquitin-Proteasome System) is active and limits the extent of potentiation. This helps to prevent excessive strengthening of synapses, ensuring that neural networks remain flexible and adaptable. This process involves the targeted degradation of proteins, including those involved in synaptic potentiation, by the proteasome complex. The depolymerization function of cofilin is not necessarily enhanced during stabilizing of a potentiated synapse, but rather is involved in the initial induction of synaptic potentiation. Calpain proteins may be activated during synapse potentiation, but their activity likely contributes to the induction of potentiation rather than its stabilization. Phosphorylated GluA1 receptors are able to influx calcium during synaptic potentiation, and their phosphorylation is a key mechanism underlying the strengthening of synapses.

Which Occurs During the Stabilizing of a Potentiated Synapse