The synaptic tag and capture hypothesis was proposed to explain how plasticity products (mRNA and protein) get targeted to the correct synapses.

Question

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The synaptic tag and capture hypothesis proposes that plasticity products are tagged with a molecular marker at the synapse where they are produced, and then captured by and incorporated into only those synapses that have been recently active and have the appropriate molecular receptors to recognize the tag. This allows for targeted plasticity and avoids indiscriminate changes in synaptic strength.

The Synaptic Tag and Capture Hypothesis Was Proposed to Explain