The Synapse-To-Nucleus Hypothesis Proposes That Genomic Signaling _______

The synapse-to-nucleus hypothesis proposes that genomic signaling _______. (Select all that apply.)

A) is initiated directly in the synapse
B) does not depend on voltage-dependent calcium channels
C) is the result of calcium entering the soma from voltage depend calcium channels
D) requires molecules to translocate from the synapse to the nucleus
E) None of the above