The nineteenth-century author Oliver Wendell Holmes was the first high-profile American citizen to bring attention to the abuse of drugs by poets, artists, and actors in his novel On Thin Ice, published in 1889.

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Oliver Wendell Holmes did write about drug abuse in his works, but he did not specifically mention poets, artists, and actors in On Thin Ice, which was actually a collection of essays rather than a novel. The first high-profile American to publicly address drug abuse in the arts was actually the poet and physician William Carlos Williams in his essay "The Artist Stripped Bare" published in 1922.

The Nineteenth-Century Author Oliver Wendell Holmes Was the First High-Profile