What historical event inaugurated the Hellenistic era of Greek civilization?

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Alexander the Great's conquests in Egypt, Mesopotamia, and Asia marked the beginning of the Hellenistic era, which was characterized by a blending of Greek and Eastern cultures and a spread of Greek influence throughout the Mediterranean and beyond. This era lasted from the death of Alexander in 323 B.C. to the Roman conquest of Egypt in 30 B.C.

What Historical Event Inaugurated the Hellenistic Era of Greek Civilization