Degenerative changes in the pre-frontal cortex and hippocampus can be due to ______.

Question

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Hyperactivation of the hypothalamic-pituitary-adrenal axis leads to increased production of glucocorticoids, which can cause degenerative changes in the pre-frontal cortex and hippocampus. Increased support by neuroglia or increased number of astrocytes do not necessarily cause degenerative changes, and reduced levels of glucocorticoids would actually be beneficial for these brain regions.

Degenerative Changes in the Pre-Frontal Cortex and Hippocampus Can Be