In normal vertebrate development, the hindbrain is distinguished from the forebrain and midbrain by the differential expression of

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Homeobox genes are responsible for specifying the different regions of the developing brain, including the hindbrain, midbrain, and forebrain. This process is known as regionalization and is essential for proper brain development. Pair-rule genes are involved in segmentation of the developing embryo, maternal polarity genes establish the anterior-posterior and dorsal-ventral axes of the embryo, and Wnt1 is a signaling molecule involved in early vertebrate development but is not specifically related to hindbrain differentiation.

In Normal Vertebrate Development, the Hindbrain Is Distinguished from the Forebrain