In which disease or disorder does genomic imprinting operate on the sex chromosomes?

Question

Quizplus · Accepted Answer

Genomic imprinting operates on the sex chromosomes in fragile X syndrome. The FMR1 gene on the X chromosome can be silenced due to methylation, which leads to a lack of expression of the FMR1 protein and results in the symptoms of fragile X syndrome. This process is an example of epigenetic regulation through genomic imprinting. Hemophilia, sickle cell anemia, and phenylketonuria are all genetic disorders that do not involve genomic imprinting on the sex chromosomes.

In Which Disease or Disorder Does Genomic Imprinting Operate on the Sex