The most predictive feature of an antipsychotic's propensity to cause extrapyramidal symptoms is

Question

Quizplus · Accepted Answer

Extrapyramidal symptoms (EPS) are caused by the blockade of dopamine D₂ receptors in the basal ganglia, so the most predictive feature of an antipsychotic's propensity to cause EPS is how tightly it competes for D₂ receptors in the basal ganglia. Antipsychotics with a high affinity for D₂ receptors are more likely to cause EPS, while those with a low affinity for D₂ receptors are less likely to cause EPS.

The Most Predictive Feature of an Antipsychotic's Propensity to Cause