Tricyclic antidepressants

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Quizplus · Accepted Answer

Tricyclic antidepressants bind to the reuptake transporter proteins for both serotonin and norepinephrine, causing an increase in the levels of these neurotransmitters in the synaptic cleft. They also cause long-term adaptive changes at the synapse that are related to their therapeutic effects, such as changes in gene expression and receptor density. In addition, tricyclic antidepressants have been shown to increase levels of brain-derived neurotrophic factor (BDNF), a protein involved in promoting the growth and survival of neurons. Therefore, all of the above options are correct.

Tricyclic Antidepressants