In order for a drug to pass through cell membranes, it must be

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Cell membranes are composed of a lipid bilayer, so lipid-soluble drugs are able to pass through the membrane easily. Water-soluble or hydrophilic drugs, on the other hand, have difficulty passing through the lipid bilayer and require special transport mechanisms such as channels or carriers. Hydrophobic drugs are generally lipid-soluble and would be able to pass through cell membranes.

In Order for a Drug to Pass Through Cell Membranes