Acute nicotine tolerance appears to result from

Question

Quizplus · Accepted Answer

Acute nicotine tolerance is believed to be caused by the rapid desensitization of nicotinic acetylcholine receptors (nAChRs) and the subsequent closing of cation channels. This occurs within minutes of nicotine exposure, leading to a decreased response to subsequent nicotine dosing. Long-term exposure to nicotine products may eventually lead to tolerance, but this is a separate phenomenon from acute nicotine tolerance. Rapid internalization of nAChRs is also not a known mechanism of acute nicotine tolerance.

Acute Nicotine Tolerance Appears to Result from