NMDA receptors are gated by
A) the ligand glutamate only.
B) the ligand glutamate and a strong depolarization of the membrane.
C) the ligand glutamate and the ligand AMPA.
D) a strong depolarization of the membrane.

Question

Quizplus · Accepted Answer

NMDA receptors are gated by the ligand glutamate and a strong depolarization of the membrane. Glutamate binding alone is not sufficient to open the channel, as a strong depolarization is also required to relieve the magnesium block and allow ion flux through the channel. The ligand AMPA also binds to ionotropic glutamate receptors but not specifically to NMDA receptors. Therefore, choice B is the best answer.

NMDA Receptors Are Gated by