On the basis of studies of the properties of phencyclidine (PCP), a _______ hypothesis of schizophrenia has been advanced.

Question

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Studies have shown that PCP is an NMDA receptor antagonist, blocking the action of the excitatory neurotransmitter glutamate. This has led to the proposal of the glutamate hypothesis of schizophrenia, which suggests that a dysfunction in glutamate transmission could lead to the symptoms of schizophrenia.

On the Basis of Studies of the Properties of Phencyclidine