You and your fellow deep-sea scientists have discovered a new form of marine invertebrate, and are anxious to determine the similarities and differences to animals already characterized.Chemical analysis reveals the following concentrations of permeable cations:
$$\begin{array} { | l | l | l | }
\hline \text { [on } & \text { in] } \mathrm { mM } & \text { out] } \mathrm { mM } \
\hline \mathrm { Na } ^ { + } & 50 & 450 \
\hline \mathrm { K } ^ { + } & 420 & 20 \
\hline \mathrm { Mg } ^ { + + } & 10 & 60 \
\hline \mathrm { Cl } ^ { - } & 50 & 550 \
\hline
\end{array}$$
Nernst equation: E ion = 61/z × log [ion] out /[ion] in
-Control of the neuromuscular junction in this new invertebrate is found to involve dual innervation, where one motor neuron secretes an excitatory neurotransmitter and another secretes an inhibitory neurotransmitter onto the muscle.How does this compare to the human neuromuscular junction? Propose three different types of inhibitory receptors/channels that would produce inhibition of the invertebrate muscle, specifying ion and direction of ion flow.For each ion, calculate the equilibrium potential.What similarity do you notice in the equilibrium potentials of the ions involved, and how is that significant? How may inhibition be accomplished in human muscle?

Question

You and your fellow deep-sea scientists have discovered a new form of marine invertebrate, and are anxious to determine the similarities and differences to animals already characterized.Chemical analysis reveals the following concentrations of permeable cations:
 $$\begin{array} { | l | l | l | } 
\hline \text { [on } & \text { in] } \mathrm { mM } & \text { out] } \mathrm { mM } \
\hline \mathrm { Na } ^ { + } & 50 & 450 \
\hline \mathrm { K } ^ { + } & 420 & 20 \
\hline \mathrm { Mg } ^ { + + } & 10 & 60 \
\hline \mathrm { Cl } ^ { - } & 50 & 550 \
\hline
\end{array}$$ 
Nernst equation: E ion = 61/z × log [ion] out /[ion] in 
-Control of the neuromuscular junction in this new invertebrate is found to involve dual innervation, where one motor neuron secretes an excitatory neurotransmitter and another secretes an inhibitory neurotransmitter onto the muscle.How does this compare to the human neuromuscular junction? Propose three different types of inhibitory receptors/channels that would produce inhibition of the invertebrate muscle, specifying ion and direction of ion flow.For each ion, calculate the equilibrium potential.What similarity do you notice in the equilibrium potentials of the ions involved, and how is that significant? How may inhibition be accomplished in human muscle?

Quizplus · Accepted Answer

The Answer of You and your fellow deep-sea scientists have discovered a new form of marine invertebrate, and are anxious to determine the similarities and differences to animals already characterized.Chemical analysis reveals the following concentrations of permeable cations:
 $$\begin{array} { | l | l | l | } 
\hline \text { [on } & \text { in] } \mathrm { mM } & \text { out] } \mathrm { mM } \
\hline \mathrm { Na } ^ { + } & 50 & 450 \
\hline \mathrm { K } ^ { + } & 420 & 20 \
\hline \mathrm { Mg } ^ { + + } & 10 & 60 \
\hline \mathrm { Cl } ^ { - } & 50 & 550 \
\hline
\end{array}$$ 
Nernst equation: E ion = 61/z × log [ion] out /[ion] in 
-Control of the neuromuscular junction in this new invertebrate is found to involve dual innervation, where one motor neuron secretes an excitatory neurotransmitter and another secretes an inhibitory neurotransmitter onto the muscle.How does this compare to the human neuromuscular junction? Propose three different types of inhibitory receptors/channels that would produce inhibition of the invertebrate muscle, specifying ion and direction of ion flow.For each ion, calculate the equilibrium potential.What similarity do you notice in the equilibrium potentials of the ions involved, and how is that significant? How may inhibition be accomplished in human muscle?

You and Your Fellow Deep-Sea Scientists Have Discovered a New