Which of the following would cause the crossbridge to transition from a high force state to a low force state?
A) increasing myosin ATPase activity
B) increasing intracellular calcium
C) decreasing intracellular calcium
D) energizing the myosin head
E) decreasing myosin ATPase activity

Question

Quizplus · Accepted Answer

Crossbridge transitions from a high force state to a low force state when intracellular calcium decreases, causing the troponin-tropomyosin complex to cover the binding site on actin and prevent the interaction with myosin. Therefore, the myosin head cannot form a strong bond with actin, resulting in a decrease in force generation.

Which of the Following Would Cause the Crossbridge to Transition