Do the factors affecting affinity of hemoglobin for oxygen have the same impact on loading and unloading in lungs and tissues? Explain your answer, and indicate if this presents a conflict in remedying hypoxia.Assuming a medical team has treatments available for changing all the factors affecting hemoglobin's oxygen affinity, how should they manipulate pH, temperature, PCO₂, and 2,3-DPG content in a hypoxic patient?
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