When two substances that have similar effects are taken at the same time, they can exacerbate the reaction (e.g., alcohol and barbiturates can cause a coma). This effect is called

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The synergistic effect occurs when two or more substances are combined and the resulting effect is greater than the sum of their individual effects. In the context of drugs or alcohol, this can lead to dangerous and unexpected outcomes, such as increased risk of coma when alcohol is combined with barbiturates.

When Two Substances That Have Similar Effects Are Taken at the Same