Which of the Following Side Effects Are Seen as Potential

Which of the following side effects are seen as potential complications to growth hormone therapy given at physiologic replacement doses?

A) slipped femoral epiphysis, pseudotumor cerebri, edema, and sodium retention
B) immunodeficiency with increased susceptibility to infections
C) unexplained development of an autoimmune disease such as Addison's disease
D) circulatory disorders such as cardiac arrhythmias, valve disease, or stroke