Which of the following are possible signs/symptoms/complications of tretinoin (Retin-A)?
I. GI hemorrhage.
II. Cerebrovascular accident
III. Disseminated intravascular coagulation (DIC)

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All the complications listed are possible with tretinoin use. Other adverse effects include multiple organ failure, hepatosplenomegaly, MIs and renal failure. Tretinoin is an antineoplastic dermatologic agent used to treat acute promyelocytic leukemias, acne vulgaris and for cosmetic purposes.

Which of the Following Are Possible Signs/symptoms/complications of Tretinoin (Retin-A)