Of the Following Methods of Administration, Which Is the Best

Of the following methods of administration, which is the best advice for a patient taking a bisphosphonate?

A) Take with as small amount of food or water as possible.
B) Take in the morning at least 30 minutes before any meal. Drink a full glass of water with the bisphosphonate.
C) Take anytime during the day when convenient.
D) Bisphosphonates should be taken at night to minimize gastric upset.