Which of the following statements is true concerning SERMs (selective estrogen receptor modulators)?
I. When using a SERM like tamoxifen, bone pain may be indicative of a good therapeutic response.
II. Individuals on SERMs may experience hot flashes.
III. Patients on SERMs must be monitored for possible thromboembolic events.
IV. At this point, it appears that all SERMs reduce the risk of breast cancer.

Question

Quizplus · Accepted Answer

All the statements are true in general of SERMs. Tamoxifen (Nolvadex) is a SERM used as an adjunct in breast cancer treatment and prevention in high-risk women. Other SERMs include clomiphene, fearelle, ormeloxifen, raloxifene and toremifine. They are also used to treat menopause, anovulation and osteoporosis. Ormeloxifene is used as a contraceptive. Bone pain is considered indicative of a positive response and should be managed with analgesics. Thromboembolic events occur more frequently in patients on all SERMs and must be monitored.

Which of the Following Statements Is True Concerning SERMs (Selective