In the concerted model for allosteric enzymes
A) the relative affinities of substrate for the T and R conformations plays an important role in the cooperativity of the reaction.
B) the equilibrium between the T and R conformations plays a minor role.
C) the enzymatic activity of the T conformation is considerably higher than that of the R form.
D) it is possible to describe the reactions of all allosteric enzymes accurately.

Question

Quizplus · Accepted Answer

The concerted model for allosteric enzymes, also known as the Monod-Wyman-Changeux (MWC) model, posits that allosteric proteins exist in an equilibrium between tense (T) and relaxed (R) states. The substrate has a higher affinity for the R state, and binding of substrate to one site increases the affinity of other sites for the substrate (positive cooperativity). Thus, the relative affinities of the substrate for the T and R conformations are crucial for the cooperativity observed in the reaction.

In the Concerted Model for Allosteric Enzymes