Which of the following is not a difference between the concerted model and the sequential model of allosteric enzymes?
A) The sequential model allows for different subunits to be in different conformations while the concerted model does not
B) Negative cooperativity can be explained by the sequential model but not by the concerted model
C) Positive cooperativity can be explained by the sequential model but not by the concerted model
D) The sequential model is explained better by considering the induced-fit model of substrate binding, whereas the concerted model focuses on perturbing the equilibrium between the T and R forms.

Question

Quizplus · Accepted Answer

The concerted model can explain positive cooperativity, which is a hallmark of allosteric enzymes. Both the concerted and sequential models account for positive cooperativity, where the binding of a substrate to one active site increases the affinity of other active sites for their substrates. The key difference lies in how they explain the transition between different states of the enzyme: the concerted model proposes that enzyme subunits change conformation simultaneously, while the sequential model allows for a stepwise change in conformation of individual subunits.

Which of the Following Is Not a Difference Between the Concerted