Most difficult criterion to establish causal association in etiology of disease is

Name: Most difficult criterion to establish causal association in etiology of disease is
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Specificity of association is often the most difficult criterion to establish in the etiology of disease because many diseases can be caused by multiple factors, and a single factor can contribute to multiple diseases. This makes it challenging to pinpoint a one-to-one relationship between a cause and its effect.

Most Difficult Criterion to Establish Causal Association in Etiology of Disease