Which one of these is not an approach to make the drug cross the blood-brain barrier?

Question

Quizplus · Accepted Answer

The use of highly lipophilic drugs only is not an approach to make drugs cross the blood-brain barrier (BBB) by itself. While lipophilicity can aid in passive diffusion across cell membranes, including the BBB, relying solely on a drug's lipophilicity without considering other strategies or the specific properties of the BBB is not a comprehensive or effective approach to enhancing BBB permeability. Other methods, such as using permeation enhancers, osmotic disruption of the BBB, and employing drug carriers, are active strategies designed to facilitate or enable the crossing of drugs through the BBB.

Which One of These Is Not an Approach to Make