The renal clearance of a drug bound to plasma protein is increased after displacement with another drug.

Name: The renal clearance of a drug bound to plasma protein is increased after displacement with another drug.
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Question

Quizplus · Accepted Answer

When a drug that is bound to plasma proteins is displaced by another drug, it increases the free (unbound) concentration of the first drug in the plasma. This increase in free drug concentration enhances its filtration through the renal glomerulus, thereby increasing its renal clearance.

The Renal Clearance of a Drug Bound to Plasma Protein