The most likely mechanism of antihypertensive action of thiazide diuretics in the long-term is:

Question

Quizplus · Accepted Answer

Thiazide diuretics initially reduce blood pressure by decreasing blood volume and cardiac output. However, their long-term antihypertensive effect is primarily due to a reduction in total peripheral vascular resistance and improved compliance of resistance vessels, not sustained reductions in volume or cardiac output.

The Most Likely Mechanism of Antihypertensive Action of Thiazide Diuretics