The metabolic pathway of detoxification that become increasingly important in paracetamol toxicity is

Question

Quizplus · Accepted Answer

Cytochrome p450 dependent glutathione conjugation becomes increasingly important in paracetamol (acetaminophen) toxicity. This pathway helps in detoxifying the toxic metabolite NAPQI (N-acetyl-p-benzoquinone imine) produced by the cytochrome P450 system from paracetamol. When glutathione stores are depleted, this pathway is overwhelmed, leading to liver damage.

The Metabolic Pathway of Detoxification That Become Increasingly Important in Paracetamol