The model or classic case of hemolytic disease of the fetus and newborn (HDFN)involves an

Question

Quizplus · Accepted Answer

HDFN occurs when the mother is Rh(D)-negative and her fetus is Rh(D)-positive, and the mother develops anti-D antibodies against the Rh(D) antigen on the fetal red blood cells. This happens when fetal blood enters the mother's bloodstream during pregnancy or childbirth, and the mother's immune system recognizes the Rh(D) antigen as foreign and mounts an immune response against it. The antibodies can cross the placenta and attack the fetal red blood cells, leading to hemolysis and subsequent anemia, jaundice, and other complications in the newborn. Anti-A antibodies (choice A) would not cause HDFN in this scenario because the mother and fetus are both Rh(D)-negative and do not express the ABO blood group antigens. Choice C is incorrect because anti-A,B antibodies are not typically associated with HDFN, and the mother's Rh(D) status is not relevant in this case. Choice D is incorrect because a Rh(D)-positive mother would not produce anti-D antibodies against her Rh(D)-negative fetus.

The Model or Classic Case of Hemolytic Disease of the Fetus