What is defined as a process whereby a drug is broken down, changed, or combined with other substances to render it physiologically inactive?

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Biotransformation is defined as a process whereby a drug is broken down, changed, or combined with other substances to render it physiologically inactive. Biotransformation has two chemical groups: esters and amides. Esters are metabolized in plasma through the process of hydrolysis. Amides are metabolized in the liver. Cirrhosis, alcoholism, liver disease, and jaundice may affect the rate of biotransformation.

What Is Defined as a Process Whereby a Drug Is