Acute rheumatic fever classically develops in children 1 to 4 weeks after a group A hemolytic streptococcal (Streptococcus pyogenes) infection of which of the following organs?

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Rheumatic fever (RF) is a systemic disease with the major findings of migratory polyarthritis of large joints, carditis, erythema marginatum of skin (although skin involvement is not very common), subcutaneous nodules, and Sydenham's chorea.

Acute Rheumatic Fever Classically Develops in Children 1 to 4