A Hypertensive Patient Who Has Elevated Serum Cholesterol Wants to Get

A hypertensive patient who has elevated serum cholesterol wants to get screened for endothelial dysfunction. Which of the following methods can be used for diagnostic screening of endothelial dysfunction?

A) Iontophoresis with acetylcholine, intra-arterial administration of vasoactive agents, localized heating of the skin, and temporary arterial occlusion using a blood pressure cuff
B) Iontophoresis with acetylcholine, intra-venous administration of vasoactive agents
C) Iontophoresis with acetylcholine, intra-venous administration of vasoactive agents, exposing the skin to cold
D) Iontophoresis with adrenaline, intra-arterial administration of vasoactive agents