A 66-year-old black woman diagnosed with stage III colon cancer underwent definitive resection of the primary tumor 3 years ago. After surgery, she received adjuvant chemotherapy with 5-fluorouracil and leucovorin. Approximately 20 months later, she developed metastatic disease in the liver (five lesions in right and left lobe) and lungs (one lesion in the right and left lobe). She was treated with irinotecan, 5-fluorouracil, and leucovorin, and had a partial response to therapy. One month ago, disease progression was documented on restaging CT scans. The patient"s laboratory studies show relatively normal organ function. She has fatigue, decreased appetite, and has noticed a 2.3-kg (5-Ib) weight loss over the past 3 months. She has stopped participating in weekend bike trips with a cycling club, but remains involved in church and family activities and states that she wants to be as aggressive as possible in fighting the cancer. What is the most reasonable recommendation for this patie

Question

Quizplus · Accepted Answer

Given the patient's history of colon cancer with metastases and progression after first-line therapy, a second-line chemotherapy regimen with leucovorin and oxaliplatin (FOLFOX) is a standard approach. This regimen is effective in patients who have previously been treated with a regimen including 5-fluorouracil and irinotecan.

A 66-Year-Old Black Woman Diagnosed with Stage III Colon Cancer