A 62-Year-Old Postmenopausal Woman with a Family History of Breast

A 62-year-old postmenopausal woman with a family history of breast cancer in two first-degree relatives wishes to consider taking tamoxifen to reduce her risk of breast cancer. Her baseline risk of breast cancer qualifies her for consideration of tamoxifen (i.e., an absolute risk of at least 1.66% over the next 5 years) . She has had a prior hysterectomy, but her ovaries are intact. Which of the following effects of tamoxifen are relevant to the decision?

A) Decreased risk of myocardial infarction or ischemic heart disease
B) Increased risk of deep venous thrombosis
C) Increased risk of ovarian cancer
D) Increased risk of major depression
E) Increased risk of colorectal cancer