26- A 60-year-old man was diagnosed last year with adenocarcinoma of the lung, and a 4 cm mass lesion was treated with a right lower lobectomy. He now has an abdominal CT scan that reveals scattered hepatic mass lesions and hilar lymphadenopathy. For several weeks, he has had increasing malaise. A urinalysis reveals marked proteinuria, and a 24 hour urine protein collection is 2.7 g/24hr. His serum urea is 30 mmol/L (2.5 - 7.5) with creatinine of 450 µmol/L (60 - 110). A renal biopsy is performed, and there is focal deposition of IgG and C3 with a granular pattern. He is most likely to have which of the following conditions?

Question

Quizplus · Accepted Answer

The patient's presentation of marked proteinuria, a 24-hour urine protein collection of 2.7 g/24hr, and renal biopsy findings showing focal deposition of IgG and C3 with a granular pattern are indicative of Membranous glomerulonephritis. This condition is often associated with malignancies, such as adenocarcinoma of the lung, which the patient has been diagnosed with.

26- a 60-Year-Old Man Was Diagnosed Last Year with Adenocarcinoma