Which of the following genetic abnormalities is most commonly associated with Ewing sarcoma?
A)t(8;14)
B)t(11;22)
C)1p/19q gene deletion
D)Loss of heterozygosity (LOH) of the retinoblastoma gene

Question

Quizplus · Accepted Answer

Ewing sarcoma is most commonly associated with the translocation t(11;22)(q24;q12), which results in the fusion of the EWSR1 gene on chromosome 22 to the FLI1 gene on chromosome 11. This genetic abnormality is characteristic of Ewing sarcoma and helps differentiate it from other types of tumors.

Which of the Following Genetic Abnormalities Is Most Commonly Associated