The Supreme Court in Hughes v. Oklahoma held that when states have a "compelling interests" in regulating an area, such as environmental protection, that interest supersedes the Commerce Clause.

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In Hughes v. Oklahoma, the Supreme Court ruled that state laws that clearly discriminate against interstate commerce are generally struck down unless the state can show that it has no other means to advance a legitimate local interest. The case emphasized the supremacy of the Commerce Clause over discriminatory state regulations, not the supremacy of state interests over the Commerce Clause.

The Supreme Court in Hughes V